// Pillar IV
Cannabinoids and pain, tumour research, anxiety, insomnia, opioid alternatives — the real human stakes of cannabis science.
United Cannabis standardised sublingual formulations with EHR patient tracking. Five profiles targeting different therapeutic applications from THCA to CBN sleep blends.
Ep. 003
Cannabinoid formulations converted to esters for IV administration. Dr. David Allen predicts ambulances will carry these for heart attacks, strokes, and acute emergencies.
Ep. 016
Topical products designed to cross the skin barrier and deliver cannabinoids systemically. Paired with specific carrier oils for targeted therapeutic applications.
Ep. 016
A dosing protocol layering raw cannabinoids (daytime, non-psychoactive) and activated cannabinoids (evening, therapeutic). The "1-2-3-4" system for clinical trials.
Ep. 017
Vegetative cannabis grown for juicing — no flowers, no strong odour, less legal risk. Provides raw CBDA and THCA for non-psychoactive therapeutic use.
Ep. 018
Cold-pressed oil from hemp seeds with zero cannabinoids, distinct from CBD extract.
Ep. 023
Lipid bilayer spheres encapsulating cannabinoids for water-compatible delivery.
Ep. 024
Rare condition from sustained high THC causing ECS shutdown in ~1% of young heavy users.
Ep. 024
Standardised formulations in active and inactive forms for structured dosing.
Ep. 024
A rare, severe form of intractable epilepsy that typically begins in infancy, characterized by frequent, prolonged seizures and developmental delays.
Ep. 031
A cannabis-derived oil preparation rich in cannabidiol (CBD), a non-psychoactive cannabinoid.
Ep. 031
The therapeutic application of cannabis to treat Crohn's disease, a chronic inflammatory bowel condition.
Ep. 035
The proportional relationship between different cannabinoids (typically THC to CBD) in a cannabis preparation, expressed as ratios like 1:1, 3:1, 10:1, or 30:1.
Ep. 035
Oral dosage forms where cannabis oil is encapsulated in gelatin or vegetable capsules for consistent, measured dosing.
Ep. 035
The therapeutic use of cannabis-derived medicines in children, typically for severe conditions like intractable epilepsy, Crohn's disease, and other life-threatening pediatric illnesses.
Ep. 035
The potential therapeutic application of cannabis to manage celiac disease, an autoimmune disorder triggered by gluten that damages the small intestine lining.
Ep. 035
The practice of selecting specific cannabis cultivars with known cannabinoid and terpene profiles to treat particular medical conditions.
Ep. 037
The process of gradually adjusting CBD dosage upward or downward to find the optimal therapeutic amount for a specific patient.
Ep. 037
Cannabis preparations, typically high in CBD and low in THC, used to reduce seizure frequency and severity in epilepsy patients.
Ep. 037
A high-CBD cannabis cultivar named after Haley Jade Rose, a child with Dravet syndrome whose seizures were dramatically reduced by this strain.
Ep. 037
A method of administering cannabis oil medicine rectally via suppositories, allowing for high-dose cannabinoid absorption without the psychoactive effects associated with oral or inhaled delivery.
Ep. 036
A therapeutic protocol using concentrated cannabis oil, typically made via alcohol extraction and fully purged, administered orally, as suppositories, or topically to treat serious conditions…
Ep. 036
Cannabis oil produced without the use of chemical solvents. Considered preferable for immune-compromised patients because it eliminates the risk of residual solvent contamination.
Ep. 036
Therapeutic use of cannabis to manage PTSD symptoms including hypervigilance, insomnia, anxiety, flashbacks, and emotional dysregulation.
Ep. 042
Story of Michaela Comto, a pediatric cancer patient whose family turned to cannabis oil when conventional oncology offered little hope, becoming a prominent advocacy case.
Ep. 042
Use of cannabis to manage depression symptoms through interaction with the endocannabinoid system, particularly via CB1 receptor activation.
Ep. 042
Use of cannabis to reduce intraocular pressure (IOP) in glaucoma patients. THC lowers fluid pressure in the eye.
Ep. 042
Term coined by Dr. Lester Grinspoon for using cannabis as complement to conventional treatments. Positions cannabis as synergistic addition, not replacement.
Ep. 044
Widespread use of cannabis as ingredient in mainstream medicines prior to 1937 Marijuana Tax Act, evidenced by preserved medicine bottles.
Ep. 050
A developed allergic sensitivity to cannabis pollen, trichomes, or terpene vapors that can occur with prolonged occupational exposure, requiring respirators or PPE for hash makers and trimmers.
Ep. 210
The practice of tailoring cannabis dosage amount, cannabinoid ratios, and delivery methods (oral, transdermal, suppository, inhalation) to specific medical conditions.
Ep. 054
Emerging research showing that cannabinoids may help address Alzheimer's disease by reducing amyloid-beta plaque buildup on brain receptors.
Ep. 054
The use of cannabis to treat mental health conditions including PTSD, anxiety, depression, and other psychological disorders.
Ep. 054
The use of cannabis and cannabis concentrates to manage Complex Regional Pain Syndrome (CRPS), a chronic neurological condition causing severe, persistent pain typically in a limb.
Ep. 052
The medical principle that the full spectrum of cannabinoids, terpenes, and other plant compounds in cannabis works synergistically for therapeutic benefit, rather than isolated single compounds like…
Ep. 054
The practice of vaporizing dried lavender flowers for their therapeutic benefits, particularly the healing properties of French lavender (Lavandula) on the respiratory system, as discussed in the…
Ep. 057
The hypothesized relationship between the pineal gland (a small endocrine gland in the brain that produces melatonin and is theorized to produce DMT) and the endocannabinoid system (ECS).
Ep. 054
The role of military veterans in advocating for cannabis access, particularly for PTSD and chronic pain treatment, and their significant contribution to shifting public opinion on cannabis reform in…
Ep. 058
The practice of consuming very small amounts of cannabis to achieve subtle therapeutic or psychoactive effects without full intoxication.
Ep. 070
Seizures triggered by hormonal fluctuations during the menstrual cycle. Estrogen acts as a pro-convulsant while progesterone is an anti-convulsant, creating periods of increased seizure vulnerability.
Ep. 068
The emerging market for high-CBD cannabis flower, noted as a growing trend in 2016 as patients and consumers sought non-intoxicating cannabis options for medical use.
Ep. 067
Elvy Musikka was the first woman to receive medical cannabis from the United States federal government, winning her case in the 1980s after suing for 12 years.
Ep. 062
A theoretical condition where the body's endocannabinoid system does not produce adequate endocannabinoids for proper physiological function, potentially leading to various health issues.
Ep. 070
A severe form of childhood-onset epilepsy characterized by multiple seizure types, cognitive impairment, and an abnormal EEG pattern. It is difficult to control with conventional medications.
Ep. 068
A pharmaceutical drug containing synthetic THC (dronabinol) in sesame oil, encapsulated in a gel cap.
Ep. 061
A method of cannabis administration where drops of tincture or oil are placed under the tongue, allowing cannabinoids to absorb directly into the bloodstream through the mucous membranes, bypassing…
Ep. 068
The observed phenomenon where adding approximately 1-3% terpenes to a sublingual cannabis preparation significantly accelerates its onset and increases its effectiveness.
Ep. 062
The issue of medical cannabis patients requiring access to concentrated forms like hash, sift, and rosin for adequate pain relief, and the threat of regulations that would remove concentrates from…
Ep. 073
Concerns about the safety of cannabis vaporizer pens, particularly regarding interior components like wires, glues, and non-medical-grade materials that users may unknowingly be inhaling when the…
Ep. 073
A cannabis topical or concentrate product mentioned in Hash Church episode 72, described as a noteworthy cannabis medicine preparation.
Ep. 073
The growing movement of professional athletes, particularly retired NFL players, openly advocating for cannabis use to manage chronic pain, injuries, and CTE symptoms as an alternative to opioid…
Ep. 078
The use of cannabis concentrates, particularly hash rosin and full melt hash, as an alternative to pharmaceutical painkillers for managing chronic spinal pain and post-surgical recovery.
Ep. 078
The use of cannabis as an alternative to pharmaceutical drugs for treating PTSD in military veterans, addressing symptoms like depression, anxiety, and suicidal ideation.
Ep. 084
The therapeutic use of cannabis for managing symptoms of Traumatic Brain Injury (TBI), a condition commonly co-occurring with PTSD in combat veterans.
Ep. 084
Research and anecdotal evidence indicating that CBD has antidepressive properties, working through different mechanisms than THC to improve mood and reduce depression symptoms.
Ep. 084
The advocacy for whole-plant cannabis medicine over isolated cannabinoids for treating veteran conditions, emphasizing the synergistic effects of all plant compounds working together.
Ep. 084
FDA-approved clinical trials studying smoked and vaporized marijuana for treating PTSD in veterans, using different THC:CBD ratios to measure therapeutic outcomes.
Ep. 086
MAPS-sponsored research into MDMA-assisted psychotherapy for treatment-resistant PTSD, which was transitioning from phase 2 to phase 3 clinical trials.
Ep. 086
The concept that different cannabis strains and cannabinoid profiles produce varying levels of sedation, allowing patients to select daytime vs nighttime medicine.
Ep. 086
Irvin Rosenfeld is one of the last surviving patients in the US federal Compassionate Investigational New Drug (IND) program, receiving government-grown cannabis from the University of Mississippi…
Ep. 088
The federal Compassionate Investigational New Drug program was established after Robert Randall's 1976 legal victory, allowing a small number of patients to receive government-grown cannabis.
Ep. 088
The cannabis provided by the US federal government through the NIDA program at the University of Mississippi was notoriously low quality - approximately 4% THC, negligible CBD, shipped in frozen tin…
Ep. 088
A case where a patient was being prosecuted based on the presence of THCV (tetrahydrocannabivarin) in their cannabis medicine, highlighting how obscure cannabinoid detection in drug testing could be…
Ep. 088
Alexander Rety's daughter was diagnosed with intractable epilepsy in September 2012 and had 18 abnormal EEGs over two years.
Ep. 093
When Canadian doctors prescribed cannabis oil under MMPR, they frequently told patients they couldn't help with dosing, drug interactions, or titration, leaving parents of epileptic children to…
Ep. 093
Seizure activity that cannot be observed visually but is detected on EEG monitoring. Alexander Rety's daughter had subclinical seizures occurring constantly even when no visible seizure was apparent.
Ep. 093
A method of making medical cannabis capsules using decarboxylated bubble hash rather than solvent-based extractions.
Ep. 092
Alexander Rety's daughter used cannabis oil at approximately a 1:21 THC-to-CBD ratio (high CBD, low THC). Her daily dosing was about 68 milligrams of CBD and 3 milligrams of THC per day.
Ep. 093
Clinical research on cannabis for inflammatory bowel disease (Crohn's and ulcerative colitis). Dr.
Ep. 096
The opioid crisis driven by prescription painkillers (oxycodone, fentanyl) and street heroin, contrasted with the safety profile of cannabis as a non-lethal analgesic alternative.
Ep. 098
The epidemic of fentanyl-related deaths caused by the synthetic opioid being cut into street drugs, making dosing unpredictable and lethal.
Ep. 098
The emerging practice of medical cannabis patients requesting specific genetics or cultivars by name based on their therapeutic needs, rather than simply asking for indica or sativa.
Ep. 099
An educational non-profit founded by journalist Fred Gardner to communicate cannabinoid science to doctors, serving as a highbrow journal that physicians could use as a reference tool for cannabis…
Ep. 102
The use of specific pressure points on the body to relieve headaches, nausea, and hangover symptoms, discussed as a complementary technique alongside cannabis for pain management.
Ep. 110
The use of cannabis to achieve full clinical remission from Crohn's disease, an inflammatory bowel disease (IBD).
Ep. 113
Scientific research into the use of cannabis for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis.
Ep. 113
Piso's Cure, one of the most popular cough medicines in the late 19th and early 20th century, which contained cannabis as an active ingredient.
Ep. 116
A simple CBD delivery formulation pairing pure CBD isolate crystals with MCT (medium-chain triglyceride) oil as carrier, creating a tincture or capsule product with consistent dosing.
Ep. 119
The approach of isolating individual cannabinoid molecules (such as pure CBD or pure THC) to create precisely dosed pharmaceutical-grade medicines, enabling reproducible recipes and accurate…
Ep. 119
Debate over whether isolated single-molecule CBD is as effective as whole-plant CBD-rich preparations.
Ep. 124
Research finding that activation of the CB2 cannabinoid receptor may be therapeutically helpful for treating psoriasis, an inflammatory skin condition.
Ep. 127
A parent education organization focused on teaching families of children with epilepsy and other serious conditions about cannabis medicine.
Ep. 131
The practice of using specific CBD-to-THC ratios in cannabis medicine rather than pure CBD or pure THC. Convention places CBD in the first position (e.g., 2:1 means twice as much CBD as THC).
Ep. 131
The demonstrated non-addictive nature of cannabis, illustrated by Bubbleman's 8-day abstinence during a Dominican Republic vacation with zero withdrawal symptoms.
Ep. 134
A legal defense strategy arguing that cannabis is not merely medically useful but biologically essential for human health, based on the endocannabinoid system being a fundamental requirement for…
Ep. 135
A medical cannabis dosing approach that distinguishes between raw (unheated, containing THCA/CBDA) and active (decarboxylated, containing THC/CBD) cannabis preparations.
Ep. 135
Regular newsletter from the International Association for Cannabinoid Medicines (IACM) that compiles direct links to the latest peer-reviewed cannabis science studies and international policy…
Ep. 129
The ongoing debate about how to detect and legislate cannabis-impaired driving, with advocates arguing that impairment-based assessment (observable behavior) is superior to nanogram blood levels,…
Ep. 130
Research being organized at UBC using measurable inflammatory biomarkers (stool and serum markers) to document the anti-inflammatory effects of cannabis in a pediatric Crohn's/Colitis patient using…
Ep. 130
A genetic connective tissue disorder (EDS) that causes chronic pain, joint hypermobility, and tissue fragility, for which some patients are finding relief through cannabis therapeutics.
Ep. 130
A medical cannabis conference focused on the latest research and regulatory obstacles. Covers regulations, obstacles to cannabis research, and the latest scientific findings across multiple days.
Ep. 164
A platform founded by Dr. Amanda Ryman in 2020 dedicated to helping people develop healthy, balanced relationships with cannabis.
Ep. 192
An approach to cannabis use that focuses on minimizing negative outcomes rather than demanding abstinence.
Ep. 192
Using cannabis to reduce or replace opioid medication for pain management.
Ep. 192
Early Israeli research using CBD plant extracts to treat children with epilepsy, which preceded and informed the development of pharmaceutical CBD products.
Ep. 198
US Patent 6,630,507 held by the Department of Health and Human Services, which establishes cannabinoids as antioxidants and neuroprotectants.
Ep. 200
Research demonstrating that CBD extracts — even crude extracts made with basic solvents — have shown ability to shrink cancerous tumors.
Ep. 200
Research establishing cannabis hyperemesis syndrome (CHS) as a genetic predisposition rather than caused by neem oil contamination. Dr.
Ep. 252
The practice of consuming very low doses of 1-5mg THC in cannabis edibles for controlled, predictable effects, recognizing that edible tolerance is independent of smoking tolerance and that liver…
Ep. 261
The extremely narrow dose range between the high-producing and lethal doses of fentanyl, requiring users to re-dose 5-7 times daily unlike heroin.
Ep. 254
The systemic failure of medical schools worldwide to teach physicians about the endocannabinoid system (ECS), despite its role as a master regulatory system governing homeostasis.
Ep. 216
A term coined by Dr. David Allen arguing that cannabinoids are not merely therapeutic but essential for basic biological function.
Ep. 216
A United States patent titled 'Cannabinoids as Antioxidants and Neuroprotectants,' held by the US Department of Health and Human Services.
Ep. 217
The concept that the body's endocannabinoid system requires specific dietary inputs - primarily short-chain fatty acids and amino acids - to produce endogenous cannabinoids like 2-AG and anandamide.
Ep. 220
The use of high-dose cannabis products, particularly edibles and concentrates, to help people reduce or eliminate dependence on harder drugs including opioids, alcohol, and methamphetamine.
Ep. 219
Per- and polyfluoroalkyl substances (PFAS) are synthetic compounds that do not degrade in the environment and accumulate in human tissue.
Ep. 220
The process by which the human gut microbiome produces endogenous cannabinoids (2-AG and anandamide) from dietary precursors including short-chain fatty acids and amino acids.
Ep. 220
A pioneering high-CBD cannabis cultivar developed by Wade Laughter, originating from a single seed that sprouted out of a batch brought from Switzerland by Lars Ruden.
Ep. 225
The phenomenon where CBD's analgesic and anti-inflammatory properties can mask underlying pain signals that serve as important diagnostic indicators, potentially causing patients to overlook disease…
Ep. 225
The nutritional classification of hemp seed and hemp seed oil as a nutraceutical food containing all essential amino acids the body cannot produce, plus omega-3, -6, and -9 fatty acids, advocated as…
Ep. 235
The practice of collecting residual resin from hookah sessions smoking live hash rosin, which converts primarily to CBN (cannabinol) through heat degradation, and using this sedative cannabinoid-rich…
Ep. 231
The practice of laboratory testing cannabis products for potency, contaminants (mold, pesticides, heavy metals, E.
Ep. 248
A network co-founded by Wade Laughter dedicated to bringing healing, dignity, and support to catastrophically ill children and their families through cannabis-based medicine and compassionate care.
Ep. 250
Colton Turner, diagnosed with severe Crohn's disease as a child, achieved remission through cannabis after three years of failed pharmaceutical treatment.
Ep. 250
Tetrahydrocannabivarin (THCV) is a cannabinoid that can suppress appetite, making it potentially dangerous for patients with wasting syndrome, Crohn's disease, or other conditions where weight…
Ep. 250
A controversial diagnostic category in the DSM-5 describing problematic cannabis use patterns.
Ep. 253
The metabolite produced when delta-9 THC is processed through the liver's first-pass metabolism after oral consumption.
Ep. 261
The science of appropriate cannabis edible dosing, complicated by extreme individual variation in metabolism.
Ep. 261
A high-dose cannabis oil protocol for cancer patients involving oral consumption of up to 1 gram of full-extract cannabis oil (FECO, also known as Rick Simpson Oil) per day.
Ep. 257
A cannabis-infused coconut oil preparation made by decarboxylating hashish and dissolving it into raw organic coconut oil.
Ep. 003
Ingesting cannabis through edibles, oils, or capsules rather than smoking or vaporizing.
Ep. 002
The practice of consuming very small, precisely measured amounts of cannabinoids throughout the day to maintain consistent therapeutic levels in the endocannabinoid system without strong psychoactive…
Ep. 003
Sublingual cannabinoid drops produced by United Cannabis, available in four formulations (P1-P4) for microdosing.
Ep. 003
The practice of taking specific amino acid supplements alongside cannabis to support the endocannabinoid system and manage pain.
Ep. 007
A dietary approach focused on feeding the body's endocannabinoid system through specific foods, supplements, and phytocannabinoids.
Ep. 011
A concentrated whole-plant cannabis extract made by soaking cannabis in a solvent (typically naphtha or isopropyl alcohol) and evaporating the solvent to leave a thick, dark oil.
Ep. 011
A holistic cannabis medicine philosophy that emphasizes using the complete range of cannabinoids, terpenes, and flavonoids present in the whole plant rather than isolating individual compounds.
Ep. 014
Hemp seed contains an ideal ratio of omega-3 to omega-6 essential fatty acids (EFAs), along with all eight essential amino acids and approximately 62% protein.
Ep. 016
The process by which CBD (cannabidiol) triggers programmed cell death specifically in cancer cells.
Ep. 016
A cannabis company (UKAN) focused on standardized cannabinoid formulations and laboratory testing.
Ep. 016
A method of extracting and activating cannabinoids by infusing them into coconut oil through gentle heating.
Ep. 014
A concept borrowed from yogic tradition, applied in cannabis to describe the vital life force energy present in whole-plant preparations.
Ep. 016
The phenomenon where experienced cannabis consumers develop heightened physical reactions to contaminants in cannabis, including pesticide residues (Avid, Forbid), chemical nutrients, and sprays…
Ep. 022
Severe, recurring headaches occurring in cyclical patterns or clusters, considered one of the most painful conditions known.
Ep. 022
Advocacy efforts in the United Kingdom to secure legal access to medical cannabis for patients suffering from chronic conditions.
Ep. 022
Rosin pressed from high-CBD cannabis plant material using heat and pressure, producing a solventless CBD-rich concentrate.
Ep. 028
A Canadian federal authorization issued under Section 56 of the Controlled Drugs and Substances Act that permitted individuals to legally possess and cultivate cannabis for medical purposes.
Ep. 029