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Crohn's Disease Cannabis Clinical Evidence

🩺 Medicine First mentioned: Ep. 096

Clinical research on cannabis for inflammatory bowel disease (Crohn's and ulcerative colitis). Dr. Natasha Ryz presented six areas where cannabis helps gut conditions: anti-nausea/vomiting, appetite stimulation for wasting, anti-inflammatory action, pain relief, stress reduction via endocannabinoid homeostasis, and symptom management. A key Israeli clinical trial by Dr. Naftali used 115mg THC smoked cannabis in 21 treatment-resistant Crohn's patients.

The Naftali trial was double-blind -- control group smoked cannabis cigarettes with THC removed. Cannabis group had less pain, less anxiety, and 3 patients discontinued steroids entirely. Terpenes (especially limonene and linalool) target gut inflammation via different pathways than cannabinoids. Cannabis signals through TRPV receptors (heat/pain), which may explain the hot-shower relief in cannabinoid hyperemesis syndrome. Dr. Ryz: PhD in experimental medicine, expert in gut barrier disruption, microbiome changes, and Th17 immune responses. Cannabis helps celiac symptoms (inflammation, pain) but won't cure gluten intolerance.

Ep. 096 Hash Church XCIV 94