// Definition
A dosing protocol developed by Tony Verzura that layers different cannabinoid forms throughout the day. Raw, inactive cannabinoids (THCA, CBDA) are used during daytime for non-psychoactive therapeutic benefits, while activated, decarboxylated cannabinoids are used at night for pain relief and deeper therapeutic effects. Doses are divided into breakfast, lunch, dinner, and bedtime, with controlled 30-minute decarboxylation increments to create different activation levels for each dose.
// From the Episode
Cannabinoid stacking was detailed by Tony Verzura in Episode 17 as part of his ACT Now patient access program. The "1-2-3-4" system was designed so clinical trials could systematically test specific cannabinoid ratios and activation levels against conditions like acute pain. The key insight is that inactive (acid-form) cannabinoids are non-psychoactive and absorb faster through the liver, making them suitable for daytime use when patients need to function. Activated cannabinoids provide stronger therapeutic effects but can impair daily function, so they're reserved for evening and bedtime doses. The 30-minute decarboxylation increments allow precise control over how much of the acid-form cannabinoid is converted to its active form, creating a spectrum of activation levels within a single daily protocol.
// Source
Ep. 017 Hash Church XVII →