// Definition
The science of appropriate cannabis edible dosing, complicated by extreme individual variation in metabolism. Some people metabolize cannabinoids very slowly and tolerate large doses while others with fast liver metabolism experience overwhelming effects at low doses. Smoking tolerance does not predict edible tolerance due to entirely different absorption and metabolic pathways.
// From the Episode
Vanessa Lavorato's cookbook emphasizes micro-dosing for enjoyable experiences. She started by putting 8 grams of hash into a dozen cookies (~266mg each) in 2010, which proved far too much. Bubbleman cannot tolerate more than 30mg despite being an extremely heavy dabber. Sublingual delivery (keeping a gummy in the mouth) provides different onset than swallowing.