// Definition
A microscopic spherical structure composed of a lipid bilayer that can encapsulate fat-soluble cannabinoids, making them compatible with water-based biological systems. Liposomes enable cannabinoid absorption through cell membranes and can be stored in body fat, potentially causing delayed onset of effects lasting many hours beyond the typical absorption window.
// From the Episode
Mark Scialdone introduced the liposome concept when discussing Tony Verzura’s sublingual cannabis formulations. He explained that plant sterols in the formulation likely create liposome-like structures that enable membrane permeability, drawing the analogy to milk where glycoproteins keep fat permanently emulsified in a water-based system. This explained a puzzling observation: a patient who consumed inactive shatter experienced no effects for 18 hours, then was “high as a kite” the next day.