// Definition
The chemical process of synthesizing THCP, which involves Lewis acid catalysts like TMS triflate (trimethylsilyl trifluoromethanesulfonate) in dichloromethane solvent at -10C. This process produces approximately 93% purity requiring chromatographic cleanup to reach 98-99%+ purity.
// From the Episode
Dr. Scialdone noted TMS triflate is prohibitively expensive at scale and the reaction conditions (chlorinated solvent at -10C) are impractical for commercial production. Cheaper alternatives like sulfuric acid or PTSA would be used commercially but may leave toxic residues. He emphasized the value of peer-reviewed literature for verifying synthesis quality via NMR spectral comparison.
// Source
Ep. 167 HC 3.0 Ep 26 →