// Definition
Essential fatty acids (EFAs) from hemp seed oil serve as precursors for endogenous cannabinoids like anandamide and 2-arachidonoylglycerol (2-AG). Arachidonic acid, a long-chain fatty acid in cell membranes, is cleaved by phospholipase A2 to initiate the arachidonic acid cascade, producing prostaglandins, leukotrienes, and endocannabinoids. Supplementing with EFA-rich hemp seed supports the endocannabinoid system.
// From the Episode
Mark Scialdone explained the biochemistry: phospholipase A2 cleaves arachidonic acid from cell membranes, starting the cascade that produces endocannabinoids and other signaling molecules. Chimera/Ryan noted EFAs either boost production or serve as precursors for these molecules. Hemp-seed-fed chickens showed elevated EFA levels in eggs. Historical context: bird feather testimony at 1930s Marijuana Tax Act hearings showed birds needed hemp seed to molt properly — the EFA connection was unknown then.
// Source
Ep. 125 Hash Church CXXII 122 →