// Definition
Research showing CBDA (cannabidiolic acid) is orders of magnitude (potentially 1000x) more bioavailable than CBD, with unique pharmacology targeting TRPV and PPAR receptors. Mechoulam's final work involved stabilizing CBDA via methylester prodrug HU-380.
// From the Episode
CBDA is extremely prone to decarboxylation making it unstable. Mechoulam developed HU-380 (methylester of CBDA) that undergoes hydrolysis in body to release CBDA. Israeli company continuing this work. Ananda Pharmaceuticals taking epidiolex through trials for endometriosis. CBGA found to completely block store-operated calcium entry (pro-inflammatory cytokine release) by Hawaiian research group - first clear target identification for acid cannabinoids in pain relief.
// Source
Ep. 252 f7zHEjw9oo8 →