// Definition
The phenomenon where pre-loading with CBD before consuming THC produces a dramatically amplified psychoactive experience, possibly through CB1 receptor upregulation or altered endocannabinoid tone. Distinct from CBD's known modulating effect when taken simultaneously with THC.
// From the Episode
Skunkman Sam described dabbing 88:1 CBD oil all day at a cup event, then smoking THC Lemon Kush — got so high he could hardly feel the concrete beneath him. Repeated the experiment: 10-12 dabs of CBD followed by banana OG 70u screened heads, got 'slammed into the farthest reaches of the universe.' Panel debated whether CBD was flushing endocannabinoid receptors or upregulating CB1.
// Source
Ep. 119 Hash Church CXVI 116 →