// Science · Glossary

Carbonium Ion Chemistry

⚗️ Science First mentioned: Ep. 126

A chemical mechanism by which CBD is converted to THC when exposed to acidic conditions. Raphael Mechoulam demonstrated this conversion decades ago, showing that as soon as CBD contacts acid, carbonium ion chemistry occurs, making the conversion thermodynamically inevitable in vitro.

Referenced by Mark Scialdone during EP126 CBD conversion debate. The key insight is that while this chemistry is unavoidable in a test tube, the human body appears to prevent it through biological mechanisms not yet fully understood.

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