// Definition
Chemical compounds produced when cannabinoids are broken down by the liver during first-pass metabolism. Oral cannabis ingestion converts a handful of cannabinoids into several dozen different metabolites through hepatic oxidation.
// From the Episode
Mark Scialdone explained that after oral ingestion, cannabinoids pass through the stomach and liver where oxidation creates dozens of metabolites. This means what the body actually receives differs significantly from what was ingested. Sublingual delivery bypasses this first-pass metabolism, reaching the brain before gut metabolic processes occur.
// Source
Ep. 068 Hash Church LXVIII 68 →